Research

Medical engineering

Multimodal medical engineering

Hideaki Haneishi

Hideaki Haneishi was born in 1963 in Tochigi, Japan. He received BS degree from University of Electro-communications in 1985. He also received MS degree in 1987 and PhD degree in 1990 from Tokyo Institute of Technology. He joined Chiba University in 1990 as a research associate. He has been a full professor of Center for Frontier Medical Engineering (CFME) since 2007. Currently he is also a vice-director of CFME. He was a visiting researcher in the period of Oct. 1995 to July 1996. He contributed a national project "Natural Vision" since 2001 until 2006 as a sub-leader. His main research interest includes medical image processing and color image processing. He is a vice-president of Japanese Society of Medical Imaging Technology (JAMIT) and served as a general chair of the JAMIT annual conference held in Chiba University in July 2016. He is also a coordinator of the project "International Network of Multimodal Medical Engineering for Precision Medicine"(2017-2021) adopted by the Japan Society for the Promotion of Science (JSPS) as a Core-to-Core Program.

"Multimodal Medical Engineering" that realizes noninvasive diagnosis by fusion of medicine and engineering

In this project, "Multimodal medical engineering," we use several modalities such as CT, MRI and US to analyze the variation of cell or organ due to disease by engineering technologies and clarify its relationship. Based on the knowledge obtained there, we aim to establish some new methods for highly precise and non-invasive diagnosis and treatment. One typical example is the development of a system for non-invasive, super-rapid intraoperative lymph node diagnosis of breast cancer with ultrasound. In the conventional routine, lymph node is dissected for metastasis discrimination of breast cancer. But this is a highly invasive way. We think that, using very high frequency ultrasound, cell characteristics in lymph node can be examined and thereby pathological diagnosis is realized non-invasively.

Rich environment for collaboration between engineering and medical researchers

This project has an environment that engineering and medical researchers tightly collaborate and conduct a wide range of researches from fundamental study to preclinical and clinical test. Many state-of-the art equipment such CT, MRI, US, endoscope, microscope and apparatus for preparing pathological specimens are also available for promoting the project.

Message to students and young researchers

In this project, we are also emphasizing the development of human resources through research activities. Students can receive education and advices from both medical and engineering professors. Thanks to active collaboration with companies, students can learn more practical mind in research and development. We also send students in the project to university or institute in foreign countries for long term or short term aiming the development of global human resources. So far, we have sent students to, for example, Harvard University, Columbia University in US, University of Eastern Finland, University of Bern, Paris 6 University in Europe, Thammasat University in Asia.

An outcome of ultrasound research

Lymph node is dissected from human body and the metastasis there can be immediately diagnosed three-dimensionally by ultrasound (US). Top row and bottom left image are US images at three different slices. Bottom right is a conventional 2D pathological image which is obtained in several days after the dissection. The immediate US image presents similar cancer detection accuracy as the pathological image.

Red in US images:
  metastasis positive
Green in US images:
  metastasis negative

Ultrasound system for analyzing biological acoustic characteristics

This system can analyze the acoustic characteristics of physiological tissue in-vivo or cultivated cells using ultrasound with a variety of wavelength in the range of KHz to GHz.

Microcirculation imaging

Microcirculation imaging We can visualize microcirculation with our prototype imaging device. The flow of red blood cells are observed. We are working on estimation of the oxygen saturation of the tissue and microcirculation.

International research collaboration

Collaboration research with University of Eastern Finland on optics-based assistance of neurosurgery. A graduate student has been staying in UEF for a half year.

Concept and direction of multimodal medical engineering

We utilize different type of modalities and/or difference scale signal (in spatial domain and/or in frequency domain) to detect biological characteristics and understand protocol of disease and develop technologies that changes conventional diagnosis and treatment.

X-ray CT and MRI equipment used for research purpose in Center for Frontier Medical Engineering