New Study Shows Glutaminase 2 Regulates Glucose Metabolism in Pancreatic β-Cells
The enzymatic conversion of glutamine to glutamate is an important mitochondrial energy pathway that is catalyzed by glutaminase 2 (GLS2). GLS2, abundant in the liver, is also found in pancreatic β-cells. However, its role in pancreatic islets involved in glucose metabolism remains mysterious. Now, researchers from Chiba University, Japan, have used in vivo experiments and human islet cell gene expression data to show that pancreatic β-cell GLS2 regulates glucose metabolism under the condition of hyperglycemia.