Detecting Cancer Cells in Blood: The Development of Microchannel Devices with Microcone Arrays

2025.07.29

Research

Despite significant advancements in biosensing technologies, the early and accurate diagnosis of cancer remains challenging. In a recent study, researchers from Japan have developed a novel microfluidic device containing arrays of microcones to detect cancer cells in the blood. Their device leverages cancer-specific antibodies as coatings to accurately detect cancer cells. Furthermore, the microchannel device maintained a high capture efficiency of more than 90%, even at high flow rates.

  • By imprinting microcones on polycarbonate sheets followed by coating with human epithelial cell adhesion molecule antibodies, scientists from Japan have developed a microchannel-based diagnostic tool. Their device demonstrated high sensitivity while maintaining a capture efficiency of more than 90% at high flow rates.